With COVID-19 vaccination efforts underway nationwide, there is an urgent need to tackle increasingly widespread misinformation about its safety, efficacy and deployment. The Internet and social media should not become major vectors for mis-information dissemination.This panel will survey public service members, practitioners, and scholars across tech, government and academia to unpack how the incoming Biden administration is shoring up efforts to address this dangerous trend, and tackle best practices for public/private sector collaboration combat this existential threat to public health.